Inorganic nanoarchitectonics designed for drug delivery and anti infective surfaces of Copper oxide

Copper oxide nanoparticles (CuONPs) have toxic effects against many microbes by generating reactive oxygen species that disrupt DNA and amino acid synthesis. It has been revealed that CuONPs have a high affinity to carboxyl and amine groups on the surface of B. subtilis cells, this affinity being higher than the interaction of silver NPs with these bacteria cells. CuONPs are also efficient against resistant bacteria pathogens, including MRSA and multidrug-resistant E. coli (Esteban et al., 2009). Single species or mixed species of these NPs were recently used to develop composed structures with antimicrobial effects, such as nano- and microspheres, nanosheets, and layer structures. Some were included in polymeric structures to ensure better biocompatibility and more efficient drug delivery. For example, in a recent study developed by our research group, a thin coating based on polylactic acid-chitosan-magnetite-eugenol (PLA-CS-Fe3O4@EUG) nanospheres was obtained by a matrix-assisted pulsed laser evaporation (MAPLE) technique. The homogeneous Fe3O4@EUG NPs, with an average diameter of about 7 nm, were included in the polymeric structures to result in 20–80 nm PLA-CS-Fe3O4@EUG nanospheres. The obtained MAPLE-deposited coatings displayed a great antimicrobial effect by impairing the adherence and biofilm formation of S. aureus and P. aeruginosa while maintaining good biocompatibility that facilitated the normal development of human cultured endothelial cells (Holban et al., 2014a,b). A recent study reported the development of gentamicin–gold nanospheres for improving antimicrobial drug delivery and biodistribution in a mouse model. These nanospheres ensured the localized delivery and controlled release of the drug at the infected areas of the utilized animal model, being highly efficient against S. aureus infection (Ahangari et al., 2013). If you are looking for high quality, high purity, and cost-effective Copper oxide, or if you require the latest price, please email contact mis-asia.