The literature evidences that CuO NPs exposure to the living systems generates reactive oxygen species, oxidative stress, inflammation, cytotoxicity, genotoxicity and immunotoxicity. Copper reacts slowly with the oxygen in the air—oxidation. The process produces copper oxide, a brown or black compound, or tarnish. Eventually, other atmospheric chemicals, like sulfur, will turn the "tarnish" blue or green. Copper, brass, and bronze do not rust for the same reason as aluminium. All three have a negligible amount of iron in them. Therefore no iron oxide, or rust, can form. However, Copper can form a blue-green patina on its surface when exposed to oxygen over time. Copper is essentially immune to corrosion. It behaves like a noble metal in most underground environments because of the naturally protective film that forms on the metal's surface. Copper will never rust for the same reason as bronze — it contains too little iron. Though it will not rust, Copper can form a green film, or patina, on its surface over time. However, this patina will not flake the way rust does. Copper is considered a noble metal and, as a result, can resist attack by oxygen. The metal is immune to corrosion due to a naturally occurring protective film known as a patina that forms on the metal's surface. If you are looking for high quality, high purity and cost-effective Copper Oxide, or if you require the latest price of Copper Oxide, please feel free to email contact mis-asia.